C1357

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C1357

Sigma-Aldrich

 

Cholecalciferol

meets USP testing specifications

Synonym:(+)-Vitamin D3, 7-Dehydrocholesterol activated, Activated 7-dehydrocholesterol, Calciol
CAS Number:67-97-0
Linear Formula:C27H44O
Molecular Weight:384.64
Beilstein Registry Number:2339331
EC Number:200-673-2
MDL number:MFCD00078131
PubChem Substance ID:24892404

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Description

Biochem/physiol ActionsVitamin D acts through a receptor that is a member of the ligand-dependent transcription factor superfamily. Modulates the proliferation and differentiation of both normal and cancer cells. Has antiproliferative and antimetastatic effects on breast, colon, and prostate cancer cells. Activated vitamin D receptors in intestine and bone maintain calcium absorbance and homeostasis.

Properties

mp83-86 °C(lit.)
suitabilitymeets USP testing specifications
storage temp.2-8°C

Safety

Hazard CodesT+
Risk Statements24/25-26-48/25
Safety Statements28-36/37
RIDADRUN 2811 6.1/PG 2
WGK Germany2
RTECSVS2900000

References

referenceLeibowitz, S.B., and Kantoff, P.W., Differentiating agents and the treatment of prostate cancer: Vitamin D3 and peroxisome proliferator-activated receptor γ ligands. Semin. Oncol. 30, 698-708, (2003)
 Welsh, J., et al., Vitamin D3 receptor as a target for breast cancer prevention. J. Nutr. 133, 2425S-2433S, (2003)
 Holick, M.F., Evolution and function of vitamin D. Rec. Res. Canc. Res. 164, 3-28, (2003)
 Palmer, H.G., et al., Genetic signatures of differentiation induced by 1α,25-dihydroxyvitamin D3 in human colon cancer cells. Cancer Res. 63, 7799-7806, (2003)
MerckMerck 13,10079
BeilsteinBeil. 6,IV,4149
 Aldrich MSDS 1, 1840:C / Corp MSDS 1 (2), 3609:A / FT-IR 2 (3), 4222:C / FT-IR 1 (2), 1049:D / FT-NMR 1 (3), 570:C / IR-Spectra (3), 1494:G / IR-Spectra (2), 1278:F / NMR-Reference 2 (2), 920:D / RegBook 1 (2), 2857:D / Sax 6, 787 / Sigma FT-IR 1 (1), 637:C / Structure Index 1, 457:B:7